Beilstein J. Org. Chem.2020,16, 337–350, doi:10.3762/bjoc.16.33
DNA-photocleavers, and are proposed as new leads for “on demand” biotechnological applications in drug discovery and medicine.
Keywords: DNA binding; DNA photocleavage; N–O homolysis; oxime carbamates; photocleavageagents; Introduction
Small organic molecules able to bind DNA provide promises for
, Figure 1) are also recognized as DNA “photocleavage” agents owing their action to the homolysis of their vulnerable N–O bond, at 312 nm [9][39][40][41][42][43] or 365 nm [44][45] yielding photogenerated carbonyloxyl radicals (CRs), which are able to cause oxidative DNA damage. We have recently reported
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Graphical Abstract
Figure 1:
General structures of oxime derivatives with possible DNA photocleavage ability. Left: Oxime carbox...